Publications and awards

Publications

Veeriah V, Zanniti A, Paone R, Chatterjee S, Rucci N, Teti A, Capulli M. Interleukin-1β, lipocalin 2 and nitric oxide synthase 2 are mechano-responsive mediators of mouse and human endothelial cell-osteoblast crosstalk. Sci Rep. 2016 Jul 19;6:29880. doi: 10.1038/srep29880. pdf available here

Teti A, Econs MJ. Osteopetroses, emphasizing potential approaches to treatment. Bone. 2017 Feb 4. pii: S8756-3282(17)30040-6. doi: 10.1016/j.bone.2017.02.002. pdf available here

Veeriah, V., Paone, R., Chatterjee, S., Teti, A., Capulli, M. Osteoblasts Regulate Angiogenesis in Response to Mechanical Unloading. Calcif Tissue Int. 2018 Nov 21. https://doi.org/10.1007/s00223-018-0496-z. pdf available here

Bateman JF, Sampurno L, Maurizi A, Lamandé SR, Sims NA, Cheng TL, Schinderler A, Little DG (2019) Effect of rapamycin on bone mass and strength in the alpha2(I)-G610C mouse model of osteogenesis imperfecta. J Cell Mol Med. 2018 Dec 30. https://doi.org/10.1111/jcmm.14072. pdf available here

Suijkerbuijk MAM, Ponzetti M, Rahim M, Posthumus M, Häger CK, Stattin E, Nilsson KG, Teti A, Meuffels DE, van der Eerden BJC, Collins M, September AV. Functional polymorphisms within the inflammatory pathway regulate expression of extracellular matrix components in a genetic risk dependent model for anterior cruciate ligament injuries.J Sci Med Sport. 2019 Jul 29. pii: S1440-2440(19)30452-9.https://doi.org/10.1016/j.jsams.2019.07.012

Tran PHT, Skrba T, Wondimu E, Galatioto G, Svensson RB, Olesen AT,  Mackey AL, Magnusson SP, Ramirez R, Kjaer M. The influence of fibrillin‐1 and physical activity upon tendon tissue morphology and mechanical properties in mice. Physiol. Rep. 2019. 7, 21, e14267. https://doi.org/10.14814/phy2.14267

Oral and poster conference presentations

Vimal Veeriah, Mattia Capulli, Angelo Zanniti, Suvro Chatterjee, Nadia Rucci, Anna Teti. Interleukin 1b (IL1b), Nitric Oxide Synthase 2 (NOS2), Lipocalin 2 (LCN2) and Vascular Endothelial Growth Factor (VEGF) Orchestrate the Coupled Mechanoresponse of Skeletal Angiogenesis and Osteogenesis – Annual Meeting of the American Society for Bone and Mineral Research Atlanta, GA September 16–19, 2016. pdf

Maurizi A, Capulli M, Patel R, Rucci N, Teti. CLCN7-dependent Autosomal Dominant Osteopetrosis type 2 (ADO2): more than a bone disease – Annual Meeting of the American Society for Bone and Mineral Research Atlanta, GA September 16–19, 2016. pdf

Antonio Maurizi, Nadia Rucci, Tina Schleicher, Yadhu Kumar, Anna Teti, Mattia Capulli. Transcriptomic Analysis of Osteoclasts from Autosomal Dominant Osteopetrosis type2 (ADO2) Mice harboring the G213R Mutation of the Chloride-Proton Antiporter type 7 (ClC7) – Annual Meeting of the American Society for Bone and Mineral Research Atlanta, GA September 16–19, 2016. pdf

Vimal Veeriah, Mattia Capulli, Suvro Chatterjee, Nadia Rucci1, Anna Teti. Vascular endothelial growth factor (VEGF) and lipocalin 2 (Lcn2) orchestrate the pro-angiogenic effects of unloaded osteoblasts – European Calcified Tissue Society Congress, May 13th-16th, 2017 Salzburg, Austria.doi: 10.1007/s00223-017-0267-2

Antonio Maurizi, Mattia Capulli, Rajvi Patel, Nadia Rucci, Anna Teti. New insights into the CLCN7-dependent autosomal dominant osteopetrosis type 2 (ADO2): a systemic disease – European Calcified Tissue Society Congress, May 13th-16th, 2017 Salzburg, Austria. doi: 10.1007/s00223-017-0267-2

Maurizi A, Capulli M, Patel R, Rucci N, Teti. A deep phenotyping of autosomal dominant osteopetrosis type 2 (ADO2) mouse model revealed multiorgan dysfunctions – International Conference on Children Bone Health held in Würzburg, Germany, on June 10-13, 2017.

Michal Dudek. Time series proteomics and phosphoproteomics reveal circadian dynamics of cartilage extracellular matrix. UK Clock Club, June 29th 2017, Bristol (Poster)

Michal Dudek. Time series proteomics and phosphoproteomics reveal daily dynamics of cartilage extracellular matrix. BSMB Autumn meeting, September 4th-5th 2017, London (Poster)

Gerjo van Osch. Adult human Mesenchymal Stem Cells and applications for cartilage repair. Seminar Hong Kong University, January 18th 2018, Hong Kong

Gerjo van Osch. Adult human Mesenchymal Stem Cells and applications for cartilage repair. Seminar Department of Orthopaedics, Chinese University of Hong Kong, January 19th 2018 Hong Kong (attendants approx. 35)

Tran PHT, Skrba T, Wondimu E, Zhang C, Galatioto J, Olesen AT, Svensson RB, Ramirez F, Magnusson SP, Kjaer M. Is aerobic exercise for everyone? The Scandinavian Congress of Medicine & Science, February 2018, Copenhagen, Denmark

Tran PHT, Skrba T, Wondimu E, Zhang C, Galatioto J, Olesen AT, Svensson RB, Ramirez F, Magnusson SP, Kjaer M. Marfan syndrome mice as a potential model for Achilles tendinopathy. Tendon UK meeting, April 2018, Oxford, UK

Gerjo van Osch. Regenerative therapy for osteoarthritis: hope or hype? Keynote lecture at OARSI World Congress, Liverpool, April 26-29 2018 (attendants approx. 200). Abstract published in Osteoarthritis and Cartilage 26, S1, April 2018, Page S5

Antonio Maurizi. Perivascular fibrosis and upregulation of the TGFβ pathway in CLCN7-dependent Autosomal Dominant Osteopetrosis type 2 (ADO2) – European Calcified Tissue Society Congress, 26-29 May, 2018 Valencia, Spain. Oral communication, http://www.ects2018.org/wp-content/uploads/2018/05/ECTS-2018-Abstract-Book.pdf

Michal Dudek. The role of the circadian clock in the homeostasis of the extracellular matrix in cartilage and intervertebral discs. Matrix Biology Europe, June 21st-24th 2018, Manchester, UK (Oral presentation)

Antonio Maurizi. Activation of the pro-fibrotic TGFβ pathway contributes to the multiorgan dysfunctions in the CLCN7-dependent ADO2 – American Society for Bone and Mineral Research Congress, 28 September – 1 October 2018 Montreal, Canada. Plenary Poster.

Gerjo van Osch. Tendinopathy. What can we learn from Osteoarthritis. Invited lecture. International Scientific Tendinopathy Symposium, 27-29 September 2018, Groningen, Netherlands (attendants approx.. 400)

Shireen Lamande. Modelling cartilage and bone disorders using human iPSCs – American Society for Matrix Biology meeting October 14-17 2018 Las Vegas NV USA (invited speaker, including results obtained in WP2.1 by Argia Ucci).

Shireen Lamande. Using iPSCs to model human cartilage diseases – 3rd National conference of the Chinese Society for Matrix Biology, November 16th-18th 2018, Hangzhou, China. (invited speaker, including results obtained by Argia Ucci)

Pavitra Kumar, Marijke Schreuders-Koedam, Jeroen Demmers, Suvro Chatterjee, Johannes P. van Leeuwen and Bram C. van der Eerden. Mucin 1 (MUC1) modulates proteomic composition of extracellular matrix from human osteoblasts under hypoxia. Dutch Calcium and Bone Metabolism Society, 15-16 November 2018, Zeist, the Netherlands. Oral presentation.

S Dlamini, CJ Saunders, J Gamieldien, A Gibbon, M Collins, AV September. Development and application of a biological network mapping strategy to identify susceptibility loci for musculoskeletal soft tissue injuries. Dutch Calcium and Bone Metabolism Society, 15-16 November 2018, Zeist, the Netherlands. Oral presentation.

Tran PHT, Skrba T, Wondimu E, Zhang C, Galatioto J, Olesen AT, Svensson RB, Ramirez F, Magnusson SP, Kjaer M. Fibrillin deficiency leads to weakened, smaller tendons in both trained and untrained mice. PhD School University of Copenhagen, MUSKOS, December 2018, Helsingør, Denmark

Tran PHT, Skrba T, Wondimu E, Zhang C, Galatioto J, Olesen AT, Svensson RB, Ramirez F, Magnusson SP, Kjaer M. Trained and untrained mice with Fibrillin deficiency have smaller, weakened tendons. Bispebjerg Hospital, Annual Scientific Meeting, December 2018, Copenhagen, Denmark

Pavitra Kumar, Marijke Schreuders-Koedam, Jeroen Demmers, Suvro Chatterjee, Johannes P. van Leeuwen and Bram C. van der Eerden. Mucin-1 modulates proteomic composition of extracellular matrix of human osteoblasts under hypoxia. Science days Internal Medicine, 10-11 January 2019, St Michelsgestel, the Netherlands. Poster presentation.

S Dlamini, CJ Saunders, J Gamieldien, A Gibbon, M Collins, AV September. Development and application of a biological network mapping strategy to identify susceptibility loci for musculoskeletal soft tissue injuries. Science days Internal Medicine, 10-11 January 2019, St Michelsgestel, the Netherlands. Poster presentation.

S Dlamini, CJ Saunders, J Gamieldien, A Gibbon, M Collins, AV September. Development and application of a biological network mapping strategy to identify susceptibility loci for musculoskeletal soft tissue injuries. Molecular Medicine day, 14 March 2019, Rotterdam, the Netherlands. Poster presentation.

Mathijs Suijkerbuijk, European College of Sports Science congress Jul 03 – 06, 2019, Prague, oral presentation of two abstracts:

  • Functional polymorphisms within the inflammatory pathway regulate expression of extracellular matrix components in a genetic risk dependent model for anterior cruciate ligament injury
  • Investigation of three independent population strengthens the hypothesis that genetic loci within the proteoglycan and angiogenesis-associated pathways predispose to anterior cruciate ligament injury

Marco Ponzetti, Argia Ucci and Antonio Maurizi. Role of lipocalin-2 in muscle failure-induced bone loss in the MDX mouse model of Duchenne muscle dystrophy – European Calcified Tissue Society Congress, 11-14 May 2019, Budapest, Hungary.

Antonio Maurizi. Transcriptomic approach to gain insights on multiorgan alterations affecting a mouse model of autosomal dominant osteopetrosis type2 (ADO2) – European Calcified Tissue Society Congress, 11-14 May 2019, Budapest, Hungary.

Marco Ponzetti, Argia Ucci and Antonio Maurizi. Lipocalin 2: a possible target in DMD-induced bone loss. American Society for Bone and Mineral Research Congress, 20-23 September 2019

Antonio Maurizi. New insights into the multiorgan alterations caused in mice by the ADO2 CLCN7G213R mutation: an unbiased transcriptome approach. American Society for Bone and Mineral Research Congress, 20-23 September 2019

PhD theses

Beth Gibson (UNEW) – Results from her secondment at HKU are included in her PhD thesis “The disease mechanisms of skeletal dysplasia caused by two aggrecan mutations” which was awarded in 2018. This is available at the Newcastle University PhD thesis repository with URL: http://theses.ncl.ac.uk/jspui/handle/10443/4394

Peter Tran (REGIONH) defended his PhD thesis on January 17th 2020. The thesis is titled “The mechanisms behind the development of tendinopathy: Early structural, inflammatory, nociceptive and clinical changes”. This is currently available at http://ismc.dk/phd-disputats/pdf_thesis/PeterTran.pdf

Mathijs Suijkerbuijk (ERASMUS) – Published results from the secondment at UCT are part of his PhD thesis that was defended January 8th 2020 and will distributed among all doctors in the Dutch Orthopedic Society. Gerjo van Osch and Alison September participated in the thesis defence committee. His thesis is available at: http://hdl.handle.net/1765/121752 (persistent URL for Erasmus repository)

Awards

Karl Kadler RUBICON participant Karl Kadler (Manchester) was awarded the prestigious Fell-Muir award at the BSMB Spring meeting in Chester on 4th April 2016, in recognition of his outstanding contribution to matrix biology. Karl delivered his prize talk, “The molecular basis of circadian clock regulation of connective tissue homeostasis”.

In June 2019, Michael Kjaer (Copenhagen) received the prestigious KFJ Award for his work on physical activity and physiology focusing on the connective tissue.
https://healthsciences.ku.dk/newsfaculty-news/2019/06/leading-researchers-of-physical-activity-and-health-data-receive-prestigious-award/

Anna Teti
In September 2019, our coordinator Anna Teti received the prestigious ASBMR Lawrence Raisz Award at their annual meeting.