Region Hovedstaden

The Institute of Sports Medicine (ISMC), Bispebjerg Hospital, University of Copenhagen is a state institution for clinical activities and research, as well as regional centre for sports medicine that focuses on research in extracellular matrix in tendon and skeletal muscle and its adaptation to mechanical loading – basal mechanisms and clinical relevance for tissue injury, tendon overloading and age-related muscle loss. It hosts clinicians, basic researchers, integrative and clinical researchers. ISMC was recently awarded Global Excellence Center by the Regional Medical Authorities in combining research and clinical activity. The participating group is led by Professor Michael Kjaer.

Participating staff
Michael Kjaer MD PhD, Full professor of Sports Medicine, Rheumatologist, and Head of the Institute of Sports Medicine
Peter Magnusson PhD, Full professor of Physical Rehabilitation
Peter Schjerling PhD, Senior Researcher
Katja Heinemeier PhD, Associate Professor
Abigail Mackey-Sennels PhD, Associate Professor
Tanja Skrba, PhD student
Peter Tran, PhD student
Annesofie Thorup Olesen, PhD student

Relevant publications
1. Heinemeier KM, Schjerling P, Heinemeier J, Magnusson SP, Kjaer M. (2013). Lack of tissue renewal in human adult Achilles tendon is revealed by nuclear bomb 14C. FASEB J 27: 2074-9.
2. Svensson RB, Mulder H, Kovanen V, Magnusson SP: (2013). Fracture mechanics of collagen fibrils: Influence of natural cross-links. Biophysical Journal, 104: 2476-2484.
3. Beyer ML, Schjerling P, Herchenhan A, Gullberg D, Zeltz C, Heinemeier KM, Christensen L, Krogsgaard M, Kjaer M. (2014). Release of tensile strain on engineered human tendon tissue disturbs cell adhesions, changes matrix architecture, and induces an inflammatory phenotype. PLoS One, 9: e86078-e86092, 2014.
4. Nielsen RH, Holm L, Malmgaard-Clausen NM, Reitelseder S, Heinemeier KM, Kjaer M. (2014). Increase in tendon protein synthesis in response to insulin-like growth factor I (IGF-I) is preserved in elderly men. J. Appl. Physiol. 116: 42-46.
5. Nielsen RH, Couppe C, Jensen JK, Olsen MN, Heinemeier KM, Malfait F, Symons S, De Paepe A, Schjerling P, Magnusson SP, Remvig L, Kjaer M. (2014). Low tendon stiffness and abnormal ultrastructure distinguish classic Ehlers-Danlos Syndrome patients from Benign Hypermobility Syndrome patients. FASEB J, 28: 4668-4676