University of Manchester

ManchesterLogoThe University of Manchester (UMAN) is one of the world’s top 50 universities. Research is at the heart of the University, no fewer than 20 former staff and students have gone on to be Nobel laureates and the university currently has 4 Nobel laureates as members of the academic staff. The University has over 1,800 staff active in research and over £190m of funding for research earned each year. The Faculty of Life Sciences, one of the leading interdisciplinary research-focussed life science faculties in Europe with 225+ academic staff members, 260+ post doctoral researchers and 460+ postgraduate students.
The laboratory participating in RUBICON led by Professor Karl Kadler is located within the Wellcome Trust Centre for Cell-Matrix Research (www.wellcome-matrix.org), which has 21 academic laboratories that focus on a wide range of cell and matrix research including integrin biology, cartilage biology, cancer cell migration, cell adhesion, structural biology of extracellular matrix molecules, the ECM in breast biology and cancer, TGFbeta signalling, circadian clock biology, cell behaviour in a matrix environment, and mechanobiology of tissues. The Centre has an active public engagement programme towards schools and the general public. Within this Centre, the Kadler laboratory is focused on understanding how cells (tenocytes and stem cells) build a tendon.

Participating staff
Karl E. Kadler PhD, Full professor of Biochemistry
Qing Jun Meng MD PhD, Senior Research Fellow
David F. Holmes DPhil, Post doctoral fellow
Susan H. Taylor PhD, Post doctoral fellow
Tobias Starborg PhD, Senior Experimental Officer
Yinhui Lu MD, Senior Research Electron Microscope Technician
Michal Dudek PhD, Post doctoral research associate

Relevant publications
1. Kalson NS, Lu Y, Starborg T, Holmes DF and Kadler KE (2015) A structure-based expansion mechanism for fibrous tissue growth and long-range organisation. eLife, in press.
2. Yeung C-Y. C, Gossan N, Lu Y, Hughes A, Hensman JJ, Bayer M, Kjær M, Kadler KE and Meng Q-J (2014) Gremlin-2 is a BMP antagonist that is regulated by the circadian clock. * Equal corresponding authors. Scientific Reports 4: 5183 doi:10.1038/srep05183.
3. Young RD, Pinali C, Png KMY, Ralphs JR, Bushby AJ, Starborg T, Kadler KE, Knupp C and Quantock AJ (2014) Three-dimensional aspects of matrix assembly by cells in the developing cornea. Proceedings of the National Academy of Sciences U. S. A. 111: 687-692. www.pnas.org/cgi/doi/10.1073/pnas.1313561110. Featured in Science 17 January 2014: 230. [DOI:10.1126/science.343.6168.230-c] “Collagen Clarity” by Marc Lavine.
4. Kalson NS, Starborg T, Lu Y, Mironov A, Humphries SM, Holmes DF and Kadler KE (2013) Non-muscle myosin II powered transport of newly-formed collagen fibrils at the plasma membrane. Proceedings of the National Academy of Sciences U. S. A. 110: E4743-E4752. doi: 10.1073/pnas.1314348110
5. Starborg T, Kalson NS, Lu Y, Mironov A, Cootes TF, Holmes DF and Kadler KE (2013) Using transmission electron microscopy and 3View® to determine collagen fibril size and three-dimensional organization. Nature Protocols 8: 1433-1448.