ICAHN School of Medicine at Mount Sinai

SinaiLogoThe Icahn School of Medicine at Mount Sinai (ISMMS) is a Higher Education non-profit private institution with more than 1000 students MD, MD/PhD, PhD and MS students, and 700 post-doctoral fellows. Chartered in 1963, ISMMS currently operates on a $2B annual budget that includes $250M in NIH funding.
The Connective Tissue Laboratory (CTL) led by Professor Francesco Ramirez studies the multiple roles that the extracellular matrix plays in health and disease. CTL currently has 3 Assistant Professors, 1 post-doc and 3 technicians.

Participating staff
Francesco Ramirez, PhD. Full professor of Pharmacology and Systems Therapeutics
Silvia Smaldone, PhD. Assistant Professor of Pharmacology and Systems Therapeutics
Nelly Andarwis-Puri, PhD. Assistant Professor of Orthopedics

Relevant publications
1. Nistala H, Lee-Arteaga S, Smaldone S, Siciliano G, Ono R, Sengle G, Arteaga-Solis E, Levasseur R, Ducy P, Sakai LY, Karsenty G, and Ramirez F (2010) Fibrillin-1 and -2 differentially modulate endogenous TGFβ and BMP bioavailability during bone formation. J. Cell Biol. 190:1107-1121.
2. Nistala H, Lee-Arteaga S, Smaldone S, Siciliano G and Ramirez F (2010) Extracellular microfibrils modulate osteoblast-supported osteoclastogenesis by restricting TGF stimulation of RANKL production. J. Biol. Chem. 285:34126-34133.
3. Nistala H, Lee-Arteaga S, Carta L, Cook JR, Smaldone S, Siciliano G, Rifkin AN, Dietz HC, Rifkin DB, and Ramirez F (2010) Differential effects of alendronate and losartan therapy on osteopenia and aortic aneurysm in mice with severe Marfan syndrome. Hum. Mol. Genet. 19:4790-4798.